Aspose Words Unable to save using doc.save method

Hello, 

Need urgent help. Using .NET framework 4.5.2 and trying to parse and save document. 

Please advise if below is wrong.

Option 1: doc.Save(this.Response, "LetterTemplateEntity.CRSC_LETTER_TEMPLATE_DESC + doctype", ContentDisposition.Inline, null);

Option 2: doc.Save(LetterTemplateEntity.CRSC_LETTER_TEMPLATE_DESC + doctype,SaveFormat.FormatDocument, SaveType.OpenInWord, this.Response);

Just not working for me. Option 2  was old method I believe.